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Clinical reviews
TRANEXAMIC ACID TO PREVENT OBSTETRICAL HEMORRHAGE AFTER CESAREAN DELIVERY
Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network
PDF202311 pages500 KB
The study randomly assigned patients undergoing cesarean delivery at 31 U.S. hospitals to receive either tranexamic acid or a placebo after umbilical-cord clamping. The primary outcome measured was a composite of maternal death or blood transfusion by hospital discharge or 7 days postpartum. Secondary outcomes included estimated intraoperative blood loss and complications related to bleeding. The findings suggest that tranexamic acid may reduce blood loss during cesarean deliveries without significant differences in major safety outcomes.
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