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Clinical reviews
ALLERGY EVALUATION FOR IMMEDIATE PENICILLIN ALLERGY: SKIN TEST-BASED DIAGNOSTIC STRATEGIES AND CROSS-REACTIVITY WITH OTHER BETA-LACTAM ANTIBIOTICS
Kimberly G Blumenthal, MD, MSc, Roland Solensky, MD
PDF202418 pages598 KB
Penicillin allergy is the most commonly reported drug allergy, affecting up to 10 percent of patients. However, over 90 percent of those who report an allergy do not have an IgE-mediated sensitivity. The document outlines the importance of allergy evaluations to clarify individual risks and discusses the use of cephalosporins and carbapenems in patients with a history of penicillin allergy. It also provides an algorithmic approach for antibiotic choice in penicillin-allergic patients.
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