Quality Control Techniques in Hospital Radiopharmacy Combined

Nuclear Medicine

The document outlines the essential quality control tests for radiopharmaceuticals, emphasizing sterility, pyrogenicity, radionuclidic and radiochemical purity, as well as physicochemical parameters such as pH, ionic strength, and osmolality. It describes both biological tests (culture and radiometric methods) and physicochemical tests (chromatography, HPLC, ion exchange) used to ensure product safety and efficacy. Practical considerations for dilution, solvent selection, and the implementation of standard operating procedures are also discussed. The text highlights the importance of adhering to quality management systems and SOPs to maintain consistent product quality.