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Clinical reviews
MAGNESIUM ADMINISTRATION FOR VASOSPASM PREVENTION IN ACUTE ANEURYSMAL SAH: A MULTICENTER RANDOMIZED CONTROLLED TRIAL
Moinay Kim, Jeong Hoon Kim, Hyunchul Jung, Seung Bin Kim, Jun Ha Hwang, Hanwool Jeon, Yeongu Chung, Youngbo Shim, Jae Hyun Kim, Joonho Byun, Aiden Cousins, Wonhyoung Park, Jung Cheol Park, Jae Sung Ahn, Seungjoo Lee
PDF202614 pages1.1 MB
Aneurysmal subarachnoid hemorrhage (aSAH) is associated with significant morbidity and mortality, primarily due to cerebral vasospasm (CV) and delayed cerebral ischemia (DCI). This multicenter randomized controlled trial aimed to assess the neuroprotective effects of magnesium sulfate in preventing CV in aSAH patients. Conducted across four neurocritical care units in Korea, the study involved 121 patients who received either magnesium or placebo within six hours of admission. The primary outcome measured was the incidence of CV, with secondary outcomes including DCI and length of ICU and hospital stays.
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