INCLUSION BODY MYOSITIS

UC Irvine-MDA ALS and Neuromuscular Center

Inclusion body myositis (IBM) is a myopathy subtype that often presents with insidious onset and slow progression of muscle weakness, commonly misdiagnosed as a sign of aging in older adults. Recent advancements in diagnostic tools, such as specialized stains and biomarkers, have allowed for earlier recognition of the disease. The article discusses the pathogenesis of IBM, including mechanisms of autophagy and the role of T cells in its progression, as well as the challenges in treatment due to the lack of responsiveness to standard immunotherapy.