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Université de Lorraine, Centre d’Investigations Cliniques- Plurithématique, CHRU Nancy; Princess Grace Hospital, Monaco; University of Michigan School of Medicine
The article critically evaluates the use of 'old generation' potassium binders, specifically sodium polystyrene sulfonate (SPS), in managing hyperkalemia. It emphasizes the absence of randomized data supporting their chronic use and outlines the associated risks, including fluid overload and unpredictable potassium lowering. The authors advocate for newer potassium binders, such as patiromer and sodium zirconium cyclosilicate, which have shown better safety profiles and tolerability, enabling improved management of hyperkalemia in patients with chronic kidney disease.
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