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Clinical reviews
INTERFERON GAMMA - 1B FOR THE PREVENTION OF HOSPITAL - ACQUIRED PNEUMONIA IN CRITICALLY ILL PATIENTS: A PHASE 2, PLACEBO - CONTROLLED RANDOMIZED CLINICAL TRIAL
Atlanrea study group and the Société Française d’Anesthésie Réanimation (SFAR) Research Network
PDF202315 pages1.1 MB
The trial was conducted across 11 European hospitals and involved critically ill adults with acute organ failures. Patients were randomly assigned to receive either interferon gamma - 1b or a placebo. The primary outcome measured was the incidence of hospital-acquired pneumonia or all-cause mortality within 28 days. The study was halted after safety analyses indicated potential harm associated with the treatment.
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