Influenza

Gabriele Neumann, Benjamin J. Cowling, Hualan Chen, Silke Stertz, Balaji Manicassamy, Ian G. Barr, Timothy M. Uyeki & Yoshihiro Kawaoka

This document provides a comprehensive overview of influenza, covering its epidemiology, mechanisms of infection and pathogenesis, host defense mechanisms, diagnosis, prevention, and treatment. It details the public health impact of seasonal epidemics and pandemics, the viral adaptations required for cross-species transmission, and the host's innate and adaptive immune responses. Diagnostic methods like PCR and rapid antigen tests are discussed, alongside preventive strategies including annual vaccines and therapeutic options such as neuraminidase and polymerase inhibitors.