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Clinical reviews
EFFICACY AND SAFETY OF EARLY ADMINISTRATION OF 4-FACTOR PROTHROMBIN COMPLEX CONCENTRATE IN PATIENTS WITH TRAUMA AT RISK OF MASSIVE TRANSFUSION
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The PROCOAG randomized clinical trial was conducted in 12 French level I trauma centers to assess the impact of 4F-PCC on blood product consumption in patients experiencing traumatic hemorrhage. The trial involved a double-blind, randomized, placebo-controlled design, focusing on patients at risk of massive transfusion. The findings aim to inform optimal transfusion strategies in traumatic hemorrhage, an area where current practices are not well-defined.
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